Terazon2 mg

Description

Indications of Terazon 2 mg

Terazon 2 mg is indicated in- Single therapy is used to relieve from signs and symptoms of benign prostatic hyperplasia (BPH). For the treatment of hypertension.

Theropeutic Class

Alpha adrenoceptor blocking drugs, BPH/ Urinary retention/ Urinary incontinence

Pharmacology

Terazosin is an ?1-adrenoceptor antagonist which blocks peripheral postsynaptic receptors resulting to decreased arterial tone. It relaxes smooth muscle of the bladder neck causing a reduction of bladder outlet obstruction.In general, ?1-adrenergic receptors mediate contraction and hypertrophic growth of smooth muscle cells. ?1-Receptors are 7-transmembrane domain receptors coupled to G proteins, Gq/11. Three ?1-receptor subtypes, which share approximately 75% homology in their transmembrane domains, have been identified: ?1A (chromosome 8), ?1B (chromosome 5), and ?1D (chromosome 20). Terazosin is the first ?1-receptor antagonist to demonstrate selectivity for the ?1A-receptor. All three receptor subtypes appear to be involved in maintaining vascular tone. The ?1A-receptor maintains basal vascular tone while the ?1B-receptor mediates the vasocontrictory effects of exogenous ?1-agonists. Activation of ?1-receptors activates Gq-proteins, which results in intracellular stimulation of phospholipases C, A2, and D. This results in mobilization of Ca2+ from intracellular stores, activation of mitogen-activated kinase and PI3 kinase pathways and subsequent vasoconstriction. Terozosin produces its pharmacological effects by inhibiting ?1A-receptor activation. Inhibition of these receptors in the vasculature and prostate results in muscle relaxation, decreased blood pressure and improved urinary outflow in symptomatic benign prostatic hyperplasia.

Dosage & Administration of Terazon 2 mg

Benign Prostatic Hyperplasia: Initial dose: 1 mg at bedtime is starting dose of all patients and this dose should not be exceeded. Subsequent dose: The dose slowly increases to achieve the desired response. The usual recommended dose range is 5-10 mg administered once a day. Hypertension: Initial dose: 1 mg at bedtime is starting dose of all patients and this dose should not be exceeded. Subsequent dose: The dose slowly increases to achieve the desired response. The usual recommended dose range is 2-10 mg administered once a day.

Dosage of Terazon 2 mg

Benign Prostatic Hyperplasia- Initial dose: 1 mg at bedtime is starting dose of all patients and this dose should not be exceeded. Subsequent dose: The dose slowly increases to achieve the desired response. The usual recommended dose range is 5-10 mg administered once a day. Hypertension- Initial dose: 1 mg at bedtime is starting dose of all patients and this dose should not be exceeded. Subsequent dose: The dose slowly increases to achieve the desired response. The usual recommended dose range is 2-10 mg administered once a day.

Interaction of Terazon 2 mg

In patients receiving Terazosin plus ACE inhibitors or diuretics the proportion reporting dizziness or related side effects was greater than in the total population of Terazosin treated patients from clinical trials. Terazosin has been given without interaction with analgesics/anti-inflammatory, cardiac glycosides, hypoglycemic, antiarrhythmic, anxiolytics/sedatives, antibacterial, hormones/steroids and drugs used for gout.

Contraindications

Terazosin is contraindicated in patients known to be hypersensitive to Terazosin or its analogues.

Side Effects of Terazon 2 mg

Postural hypotension is more commonly reported side effect. Dizziness, lack of energy, peripheral oedema; urinary frequency and priapism reported.

Pregnancy & Lactation

The safety of Terazosin during pregnancy has not been established so Terazosin is not recommended during pregnancy unless the potential benefit justifies the potential risk to moher and fetus. It is not known whether Terazosin is excreted in breast milk. Because many drugs are excreted in breast milk, caution should be exercised when Terazosn is administered to a nursing mother.

Precautions & Warnings

First dose may cause hypotension (within 30-90 minutes). Therefore should be taken on retiring to bed. Caution should be observed when Terazosin is administered with other antihypertensive agents, avoid the possibility of significant hypotension. When adding Terazosin to a diuretic or other antihypertensive agent, dosage reduction and retitration may be necessary. The patients should be cautioned to avoid situation such as driving and hazardous tasks where injury could result due to syncope after initiation of Terazosin therapy.

Overdose Effects of Terazon 2 mg

Acute overdose may lead to acute hypotension, cardiovascular support is of first importance. Restoration of blood pressure and normalization of heart rate may be accomplished by keeping the patient in a supine position. At the same time expansion of plasma volume and noradrenergic vasopressor may also be needed.

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Drug Classes

Alpha adrenoceptor blocking drugs, BPH/ Urinary retention/ Urinary incontinence

Mode Of Action

Terazosin is selective for alpha-1-adrenoceptors but not their individual subtypes. Inhibition of these alpha-1-adrenoceptors results in relaxation of smooth muscle in blood vessels and the prostate, lowering blood pressure and improving urinary flow. Smooth muscle cells accounts for roughly 40% of the volume of the prostate and so their relaxation reduces pressure on the urethra.It has also been shown that catecholamines induce factors responsible for mitogenesis and alpha-1-adrenergic receptor blockers inhibit this effect. A final long term mechanism of terazosin and other alpha-1-adrenergic receptor blockers is the induction of apoptosis of prostate cells. Treatment with terazosin enhances the expression of transforming growth factor beta-1 (TGF-beta1), which upregulates p27kip1, and the caspase cascade

Pregnancy

The safety of Terazosin during pregnancy has not been established. So Terazosin is not recommended during pregnancy unless the potential benefit justifies the potential risk to mother and fetus. It is not known whether Terazosin is excreted in breast milk. As many drugs are excreted in breast milk, caution should be exercised when Terazosin is administered to a nursing mother.