Benzac Cream 4%
৳ 150
Overdose Effects
Benzac gel is a preparation indicated for topical treatment only. If the medication is applied excessively, no more rapid or better results will be obtained and severe irritation might develop. In this event, treatment must be discontinued and appropriate symptomatic therapy should be instituted.
Therapeutic Class
Acne treatment preparations
Storage Conditions
Store in a cool and dry place, protected from light.
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Description
Indications
Benzac is indicated for the topical treatment of mild to moderate acne vulgaris. Benzac may be used with other acne treatments including retinoic acid products, antibiotics and sulfur/salicylic acid containing preparations.
Pharmacology
Acne vulgaris is caused by inflammation in the pilosebaceous gland. Acne is generally caused by increased excretion of sebum from pilosebaceous glands, endocrine factors such as androgenic hormones, keratin developing around follicles, bacterial growth, and inflammation. These factors contribute to the formation of comedones (whiteheads and blackheads). The peroxide bond of benzoyl peroxide is cleaved to form 2 benzoyloxy radicals. These radicals interact nonspecifically with bacterial proteins, interfering with their function, and survival of the bacteria. Over time, free radical interactions with bacterial proteins lead to decreased keratin and sebum around follicles. Benzoyl peroxide can also increase the turnover rate of epithelial cells, leading to skin peeling, and breaking down comedones.
Dosage & Administration
Shake well before using. It is recommended that therapy be initiated with Benzoyl Peroxide, washing the affected areas once a day during the first week, and twice a day thereafter as tolerated. Wet skin areas to be treated; apply Benzoyl Peroxide Wash, work to a full lather, rinse thoroughly and pat dry. Frequency of use should be adjusted to obtain the desired clinical response. Close cap tightly after use.
Children: Safety and effectiveness in children below the age of 12 have not been established.
Interaction
There is no known interaction with other medications which might be used cutaneously and concurrently with Benzac; however, drugs with desquamative, irritant and drying effects should not be used concurrently with Benzac gel.
Contraindications
Benzoyl Peroxide is contra-indicated in patients with known hypersensitivity to benzoyl peroxide.
Side Effects
Allergic confact dermatitis and dryness have been reported with topical Benzac therapy. If excessive scaling, erythema or edema occurs the use of Benzac should be discontinued and appropriate therapy instituted. To hasten resolution of adverse effects, cool compresses may be used. After reaction clears, a reduced dosage schedule may often be resumed if the reaction is judged not to be due to allergenicity.
Pregnancy & Lactation
Pregnancy: Category C. Animal reproductive studies have not been conducted with benzoyl peroxide. It is also not known whether benzoyl peroxide can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Benzoyl peroxide should be used by a pregnant woman only if clearly needed. There are no available data on the effect of benzoyl peroxide on the later growth, development and functional maturation of the unborn child.
Nursing Mothers: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when benzoyl peroxide is administered to a nursing woman.
Precautions & Warnings
For external use only. Keep out of reach of children. Avoid contact with eyes, eyelids, lips and mucous membranes. If inadvertent contact occurs, rinse area thoroughly with water. Contact with colored material, including fabric and hair, may result in discoloration. When using Benzac, avoid unnecessary sun exposure and use a sunscreen. In case of accidental ingestion, seek professional assistance or contact a poison control centerimmediately.
Information for Patients:
- Avoid contact with eyes, eyelids, lips and mucous membranes.
- May discolor hair and fabrics.
- Avoid unnecessary sun exposure and use a sunscreen.
- Use of oil-free make-up recommended.
- If severe irritation develops, discontinue use and consult your physician.
Carcinogenesis, Mutagenesis and Impairment of Fertility: Studies employing a strain of mice that are highly susceptible to developing cancer suggest that Benzac acts as a tumor promoter. The clinical significance of these findings to humans is not known. Benzac has not been found to be mutagenic (Ames test) and there are no published data indicating that it impairs fertility.
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