Bemodic 180mg
৳ 30
Precautions & Warnings
Elevations in serum uric acid have occurred. Assess uric acid levels periodically as clinically indicated. Monitor for signs and symptoms of hyperuricemia, and initiate treatment with urate-lowering drugs as appropriate. Tendon rupture has occurred. Discontinue Bemodic at the first sign of tendon rupture. Avoid Bemodic in patients who have a history of tendon disorders or tendon rupture.
Storage Conditions
Store below 30ºC temperature. Keep away from light and wet place. Keep out of reach of children.
Buy 15 products and get ৳ 20 discount
0 people are viewing this right now
Estimated Delivery : Up to 4 business days
Description
Indications
Bemodic is indicated as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who require additional lowering of LDL-C.
Pharmacology
Bempedoic Acid is an adenosine triphosphate-citrate lyase (ACL) inhibitor that lowers low-density lipoprotein cholesterol (LDL-C) by inhibition of cholesterol synthesis in the liver. ACL is an enzyme upstream of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase in the cholesterol biosynthesis pathway. Bempedoic acid and its active metabolite, ESP15228, require coenzyme A (CoA) activation by very long-chain acyl-CoA synthetase 1 (ACSVL1) to ETC-1002-CoA and ESP15228-CoA, respectively. ACSVL1 is expressed primarily in the liver. Inhibition of ACL by ETC-1002-CoA results in decreased cholesterol synthesis in the liver and lowers LDL-C in blood via upregulation of low-density lipoprotein receptors.
Dosage & Administration
Administer 180 mg orally once daily with or without food.
Interaction
Simvastatin: Avoid concomitant use of Bemodic with simvastatin greater than 20 mg.
Pravastatin: Avoid concomitant use of Bemodic with pravastatin greater than 40 mg.
Pravastatin: Avoid concomitant use of Bemodic with pravastatin greater than 40 mg.
Side Effects
- Upper respiratory tract infection
- Muscle spasms
- Hyperuricemia
- Back pain
- Abdominal pain or discomfort
- Bronchitis
- Pain in extremity
- Anemia
- Elevated liver enzymes
Pregnancy & Lactation
Discontinue Bempedoic Acid when pregnancy is recognized unless the benefits of therapy outweigh the potential risks to the fetus. There are no available data on Bempedoic Acid use in pregnant women to evaluate for a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes. There is no information regarding the presence of Bempedoic Acid in human or animal milk, the effects of the drug on the breastfed infant, or the effects of the drug on milk production. Breastfeeding is not recommended during treatment with Bempedoic Acid.
Reviews
There are no reviews yet.