Aripra 15mg

Aripra 15mg

Generic: Aripiprazole

Manufacturer

Incepta Pharmaceuticals Ltd.

৳ 7

Interaction

Caution should be exercised when Aripra is taken in combination with other centrally acting drugs and alcohol. Carbamazepine could cause an increase in Aripra clearance and lower blood levels. Ketoconazole, quinidine, fluoxetine or paroxetine can inhibit Aripra elimination and cause increased blood levels.

Contraindications

Known hypersensitivity to Aripiprazole.

Side Effects

Vomiting, nausea, akathisia, extrapyramidal disorder, somnolence, sedation, dizziness, insomnia, tremor, restlessness, fatigue, blurred vision, salivary hypersecretion, constipation, pyrexia, drooling, decreased appetite.

Pregnancy & Lactation

Pregnancy category C. It should be avoided during pregnancy. It is recommended that women receiving Aripiprazole should not breast-feed.

Precautions & Warnings

Elderly Patients with Dementia-Related Psychosis: Increased incidence of cerebrovascular adverse events (eg, stroke, transient ischemic attack, including fatalities).

Suicidality & antidepressants: Increased risk of suicidality in children, adolescents, young and adults with major depressive disorder.

Tardive dyskinesia: Discontinue if clinically appropriate.

Metabolic changes: Atypical antipsychotic drugs have been associated with metabolic changes that include hyperglycemia/diabetes mellitus, dyslipidemia, and body weight gain.

Orthostatic hypotension: Use with caution in patients with known cardiovascular or cerebrovascular disease.

Seizures/Convulsions: Use cautiously in patients with a history of seizures.

Use caution when operating machinery.

Overdose Effects

Aripra at doses up to 1080 mg causes no fatalities. The signs and symptoms observed with Aripra overdose included nausea, vomiting, asthenia, diarrhea, and somnolence.

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Description

Indications

Aripra is indicated for-

  • Schizophrenia
  • Bipolar disorder
  • Adjunctive treatment of major depressive disorder
  • Irritability associated with autistic disorder
  • Agitation associated with schizophrenia or bipolar mania

  • Pharmacology

    Aripiprazole is an atypical antipsychotic and it has been proposed that the efficacy of Aripiprazole is mediated through a combination of partial agonist activity at Dopamine D2 and Serotonin 5-HT 1A receptors and antagonist activity at Serotonin 5-HT 2A receptors. This is associated with improvement of schizophrenia, bipolar disorder, major depressive disorder, irritability associated with autistic disorder, and agitation associated with schizophrenia or bipolar disorder.

    Dosage

    Schizophrenia: adults

    • Initial Dose: 10-15 mg/day
    • Recommended Dose: 10-15 mg/day
    • Maximum Dose: 30 mg/day

    Schizophrenia: adolescents (ages 13-17 years)

    • Initial Dose: 2 mg/day
    • Recommended Dose: 10 mg/day
    • Maximum Dose: 30 mg/day

    Bipolar mania: adults: monotherapy

    • Initial Dose: 15 mg/day
    • Recommended Dose: 15 mg/day
    • Maximum Dose: 30 mg/day

    Bipolar mania: adults: adjunct to lithium or valproate

    • Initial Dose: 10-15 mg/day
    • Recommended Dose: 15 mg/day
    • Maximum Dose: 30 mg/day

    Bipolar mania: pediatric patients (ages 10-17 years): monotherapy or as an adjunct to lithium or valproate

    • Initial Dose: 2 mg/day
    • Recommended Dose: 10 mg/day
    • Maximum Dose: 30 mg/day

    As an adjunct to antidepressants for the treatment of major depressive disorder: adults

    • Initial Dose: 2-5 mg/day
    • Recommended Dose: 5-10 mg/day
    • Maximum Dose: 15 mg/day

    Irritability associated with autistic disorder: pediatric patients (ages 6-17 years):

    • Initial Dose: 2 mg/day
    • Recommended Dose: 5-10 mg/day
    • Maximum Dose: 15 mg/day

    • Administration

      Oral formulations: Administer once daily without regard to meals.
      IM injection: Wait at least 2 hours between doses. Maximum daily dose 30 mg.

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