Aripra 10mg

Aripra is indicated for-

• Schizophrenia
• Bipolar disorder
• Adjunctive treatment of major depressive disorder
• Irritability associated with autistic disorder
• Agitation associated with schizophrenia or bipolar mania

• Pharmacology

  Aripiprazole is an atypical antipsychotic and it has been proposed that the efficacy of Aripiprazole is mediated through a combination of partial agonist activity at Dopamine D2 and Serotonin 5-HT 1A receptors and antagonist activity at Serotonin 5-HT 2A receptors. This is associated with improvement of schizophrenia, bipolar disorder, major depressive disorder, irritability associated with autistic disorder, and agitation associated with schizophrenia or bipolar disorder.

  Dosage

  Schizophrenia: adults

  • Initial Dose: 10-15 mg/day
  • Recommended Dose: 10-15 mg/day
  • Maximum Dose: 30 mg/day

  Schizophrenia: adolescents (ages 13-17 years)

  • Initial Dose: 2 mg/day
  • Recommended Dose: 10 mg/day
  • Maximum Dose: 30 mg/day

  Bipolar mania: adults: monotherapy

  • Initial Dose: 15 mg/day
  • Recommended Dose: 15 mg/day
  • Maximum Dose: 30 mg/day

  Bipolar mania: adults: adjunct to lithium or valproate

  • Initial Dose: 10-15 mg/day
  • Recommended Dose: 15 mg/day
  • Maximum Dose: 30 mg/day

  Bipolar mania: pediatric patients (ages 10-17 years): monotherapy or as an adjunct to lithium or valproate

  • Initial Dose: 2 mg/day
  • Recommended Dose: 10 mg/day
  • Maximum Dose: 30 mg/day

  As an adjunct to antidepressants for the treatment of major depressive disorder: adults

  • Initial Dose: 2-5 mg/day
  • Recommended Dose: 5-10 mg/day
  • Maximum Dose: 15 mg/day

  Irritability associated with autistic disorder: pediatric patients (ages 6-17 years):

  • Initial Dose: 2 mg/day
  • Recommended Dose: 5-10 mg/day
  • Maximum Dose: 15 mg/day

  • Administration

    Oral formulations: Administer once daily without regard to meals.
    IM injection: Wait at least 2 hours between doses. Maximum daily dose 30 mg.