Ambolyt 6 mg/ml

Generic: Ambroxol Hydrochloride

Manufacturer

Incepta Pharmaceuticals Ltd.

৳ 30

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Description

Indications

Ambolyt is indicated in-

  • Productive cough
  • Acute and chronic inflammatory disorders of upper and lower respiratory tracts associated with viscid mucus including acute and chronic bronchitis
  • Inflammatory disease of rhinopharyngeal tract (laryngitis, pharyngitis, sinusitis and rhinitis) associated with viscid mucus
  • Asthmatic bronchitis bronchial asthma with thick expectoration
  • Bronchiectasis
  • Chronic pneumonia etc.
  • Pharmacology

    Ambroxol is the active metabolite of bromhexine and it has been proven that this metabolite possesses a greater bronchosecretolytic effect than bromhexine. It improves sputum rheology by hydrating mechanism leading to liquefaction of mucus in the lumen of respiratory tract, thus facilitating expectoration of mucus and reducing dyspnea. It stimulates production of phospholipids of surfactant by alveolar cells, thus contributing to the lowering of superficial tension in the alveoli. It also reduces bronchial hyperactivity. Ambroxol has anti inflammatory properties owing to the inhibitory effect on the production of cellular cytokines and arachidonic acid metabolites. In patients with COPD it traditionally improves airway patency.

    Dosage & Administration

    Average daily dose (preferably after meal):

    Pediatric Drops:

    • 0-6 months: 0.5 ml 2 times a day
    • 6-12 months: 1 ml 2 times a day
    • 1-2 years: 1.25 ml 2 times a day

    Syrup:

    • 2-5 years: 2.5 ml (1/2 teaspoonful) 2-3 times a day
    • 5-10 years: 5 ml (1 teaspoonful) 2-3 times a day
    • 10 years and adults: 10 ml (2 teaspoonful) 3 times a day.

    Sustained release capsule: Adult and children over 12 years old: 1 capsule once daily.

    Interaction

    Ambolyt should not be taken simultaneously with antitussives (e.g.Codeine) because phlegm, which has been liquefied by Ambolyt might not be expectorated.

    Contraindications

    Contraindicated in known hypersensitivity to Ambroxol or Bromhexine.

    Side Effects

    Gastrointestinal side effects like epigastric pain, stomach overfill feeling may occur occasionally. Rarely allergic responses such as eruption, urticaria or angioneurotic edema have been reported.

    Pregnancy & Lactation

    Teratogenic and fetal toxicity studies have shown no harmful effect of Ambroxol. However, it is advised not to use it in pregnancy, especially during the1st trimester. Safety during lactation has not been established yet.

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