Tylen120 mg/5 ml

Description

Indications of Tylen 120 mg/5 ml

Tylen 120 mg/5 ml is indicated for fever, common cold and influenza, headache, toothache, earache, bodyache, myalgia, neuralgia, dysmenorrhoea, sprains, colic pain, back pain, post-operative pain, postpartum pain, inflammatory pain and post vaccination pain in children. It is also indicated for rheumatic & osteoarthritic pain and stiffness of joints.

Theropeutic Class

Non opioid analgesics

Pharmacology

Tylen 120 mg/5 ml has analgesic and antipyretic properties with weak anti-inflammatory activity. Tylen 120 mg/5 ml (Acetaminophen) is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis. Tylen 120 mg/5 ml is a para aminophenol derivative, has analgesic and antipyretic properties with weak anti-inflammatory activity. Tylen 120 mg/5 ml is one of the most widely used, safest and fast acting analgesic. It is well tolerated and free from various side effects of aspirin.

Dosage & Administration of Tylen 120 mg/5 ml

Tablet:

• Adult: 1-2 tablets every 4 to 6 hours up to a maximum of 4 gm (8 tablets) daily.
• Children (6-12 years): Â½ to 1 tablet 3 to 4 times daily. For long term treatment it is wise not to exceed the dose beyond 2.6 gm/day.

Extended Release Tablet:

• Adults & Children over 12 years: Two tablets, swallowed whole, every 6 to 8 hours (maximum of 6 tablets in any 24 hours).The tablet must not be crushed.

Syrup/Suspension:

• Children under 3 months: 10 mg/kg body weight (reduce to 5 mg/kg if jaundiced) 3 to 4 times daily.
• 3 months to below 1 year: ½ to 1 teaspoonful 3 to 4 times daily.
• 1-5 years: 1 -2 teaspoonful 3 to 4 times daily.
• 6-12 years: 2-A teaspoonful 3 to 4 times daily.
• Adults: 4-8 teaspoonful 3 to 4 times daily.

Suppository:

• Children 3-12 months: 60-120 mg,4 times daily.
• Children 1-5 years: 125-250 mg 4 times daily.
• Children 6-12 years: 250-500 mg 4 times daily.
• Adults & children over 12 years: 0.5-1 gm 4 times daily.

Paediatric Drop:

• Children Upto 3 months: 0.5 ml (40 mg)
• 4 to 11 months: 1.0 ml (80 mg)
• 7 to 2 years: 1.5 ml (120 mg). Do not exceed more than 5 dose daily for a maximum of 5 days.

Tylen 120 mg/5 ml tablet with actizorb technology: It dissolves up to five times faster than standard Tylen 120 mg/5 ml tablets. It is a fast acting and safe analgesic with marked antipyretic property. It is specially suitable for patients who, for any reason, can not tolerate aspirin or other analgesics.

• Adults and children (aged 12 years and over): Take 1 to 2 Tablets every four to six hours as needed. Do not take more than 8 caplets in 24 hours.
• Children (7 to 11 years): Take ½-1 Tablet every four to six hours as needed. Do not take more than 4 caplets in 24 hours. Not recommended in children under 7 years.

Interaction of Tylen 120 mg/5 ml

Patients who have taken barbiturates, tricyclic antidepressants and alcohol may show diminished ability to metabolise large doses of Tylen 120 mg/5 ml. Alcohol can increase the hepatotoxicity of Tylen 120 mg/5 ml overdosage. Chronic ingestion of anticonvulsants or oral steroid contraceptives induce liver enzymes and may prevent attainment of therapeutic Tylen 120 mg/5 ml levels by increasing first-pass metabolism or clearance.

Contraindications

It is contraindicated in known hypersensitivity to Tylen 120 mg/5 ml.

Side Effects of Tylen 120 mg/5 ml

Side effects of Tylen 120 mg/5 ml are usually mild, though haematological reactions including thrombocytopenia, leucopenia, pancytopenia, neutropenia, and agranulocytosis have been reported. Pancreatitis, skin rashes, and other allergic reactions occur occasionally.

Pregnancy & Lactation

Pregnancy category B according to USFDA. This drug should be used during pregnancy only if clearly needed

Precautions & Warnings

Tylen 120 mg/5 ml should be given with caution to patients with impaired kidney or liver function. Tylen 120 mg/5 ml should be given with care to patients taking other drugs that affect the liver.

Overdose Effects of Tylen 120 mg/5 ml

Symptoms of Tylen 120 mg/5 ml overdose in the first 24 hours are pallor, nausea, vomiting, anorexia and abdominal pain. Liver damage may become apparent 12-48 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur.

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

Drug Classes

Non opioid analgesics

Mode Of Action

Tylen 120 mg/5 ml has analgesic and antipyretic properties with weak anti-inflammatory activity. Tylen 120 mg/5 ml (Acetaminophen) is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis. Tylen 120 mg/5 ml is a para aminophenol derivative, has analgesic and antipyretic properties with weak anti-inflammatory activity. Tylen 120 mg/5 ml is one of the most widely used, safest and fast acting analgesic. It is well tolerated and free from various side effects of aspirin.

Pregnancy

Pregnancy category B according to USFDA. This drug should be used during pregnancy only if clearly needed.  Tylen 120 mg/5 ml is excreted in breast milk. Maternal ingestion of Tylen 120 mg/5 ml in normal therapeutic doses does not appear to present a risk to the nursing infant.