Nalbun20 mg/2 ml

Description

Indications of Nalbun 20 mg/2 ml

Nalbun 20 mg/2 ml Hydrochloride is indicated for the relief of moderate to severe pain. It is used for relief of moderate to severe pain associated with myocardial infarction (MI). Nalbun 20 mg/2 ml Hydrochloride can also be used as a supplement to balanced anesthesia, for preoperative and postoperative analgesia, and for obstetrical analgesia during labor and delivery.

Theropeutic Class

Opioid analgesics

Pharmacology

Nalbun 20 mg/2 ml Hydrochloride is a synthetic potent analgesic. Its analgesic potency is essentially equivalent to that of morphine on a milligram basis. Receptor studies show that Nalbun 20 mg/2 ml binds to mu, kappa, and delta receptors, but not to sigma receptors. Nalbun 20 mg/2 ml is primarily a kappa agonist/partial mu antagonist analgesic.

Dosage & Administration of Nalbun 20 mg/2 ml

The usual recommended adult dose is 10 mg for a 70 kg individual, administered subcutaneously, intramuscularly or intravenously; this dose may be repeated every 3 to 6 hours as necessary. Dosage should be adjusted according to the severity of the pain, physical status of the patient, and other medications which the patient may bereceiving.Moderate to severe pain: by intravenous or intramuscular injection 10-20 mg for 70 kg patient, adjusted as required; child up to 0.3 mg/kg repeated once or twice as necessary.Preoperative anesthesia: by intravenous or intramuscular injection 0.1-0.2 mg/kg.Obstetrical analgesia during labor & delivery: by intravenous injection 0.3-1 mg/kg over 10-15 minutes with maintenance doses of 0.25-0.5 mg/kg in single intravenous administration as required.Intraoperative analgesia: by intravenous injection 0.25-0.5 mg/kg at 30 minutes intervals.Myocardial infarction: By slow intravenous injection 10-20 mg, repeated after 30 minutes if necessary. Larger dose is required when used as supplement of anesthesia than that required for analgesia.Children from 18 months to 15 years old: usually 0.2 mg/ kg body-weight, given preferably by intravenous or intramuscular injection. Maintenance doses may be given at intervals of 4 to 6 hours or the dose must be determined by the physician.

Dosage of Nalbun 20 mg/2 ml

The usual recommended adult dose is 10 mg for a 70 kg individual, administered subcutaneously, intramuscularly or intravenously; this dose may be repeated every 3 to 6 hours as necessary. Dosage should be adjusted according to the severity of the pain, physical status of the patient, and other medications which the patient may bereceiving.Moderate to severe pain: by intravenous or intramuscular injection 10-20 mg for 70 kg patient, adjusted as required; child up to 0.3 mg/kg repeated once or twice as necessary.Preoperative anesthesia: by intravenous or intramuscular injection 0.1-0.2 mg/kg.Obstetrical analgesia during labor & delivery: by intravenous injection 0.3-1 mg/kg over 10-15 minutes with maintenance doses of 0.25-0.5 mg/kg in single intravenous administration as required.Intraoperative analgesia: by intravenous injection 0.25-0.5 mg/kg at 30 minutes intervals.Myocardial infarction: By slow intravenous injection 10-20 mg, repeated after 30 minutes if necessary. Larger dose is required when used as supplement of anesthesia than that required for analgesia.Children from 18 months to 15 years old: usually 0.2 mg/ kg body-weight, given preferably by intravenous or intramuscular injection. Maintenance doses may be given at intervals of 4 to 6 hours or the dose must be determined by the physician.

Interaction of Nalbun 20 mg/2 ml

No hazardous interactions have been identified with Nalbun 20 mg/2 ml; however, interactions described with other opioids may be anticipated. Patient receiving a narcotic analgesic, general anesthesia, phenothiazines or other tranquilizers, sedatives, hypnotics, or other CNS depressants (including alcohol) concomitantly with Nalbun 20 mg/2 ml may exhibit an additive effect.

Contraindications

Known hypersensitivity to Nalbun 20 mg/2 ml Hydrochloride.

Side Effects of Nalbun 20 mg/2 ml

Generally Nalbun 20 mg/2 ml is well tolerated. However few side-effects like sedation, sweating, nausea, vomiting, dizziness, vertigo, dry mouth, headache, respiratory depression, dyspnea and asthma may be seen.

Pregnancy & Lactation

Pregnancy category B. The placental transfer of Nalbun 20 mg/2 ml is high and rapid. There are no well-controlled studies in pregnant women. This drug should be used during pregnancy only if clearly needed. Limited data suggest that Nalbun 20 mg/2 ml is excreted in maternal milk but only in a small amount (less than 1% of the administered dose) and with a clinically insignificant effect. Caution should be exercised when Nalbun 20 mg/2 ml is administered to a nursing woman.

Precautions & Warnings

Caution should be taken in the following conditions: impaired respiration, impaired renal or hepatic function, billiary tract surgery, myocardial infarction and hypotension.

Overdose Effects of Nalbun 20 mg/2 ml

Sleepiness & mild dyspnea may occur due to overdose. The immediate intravenous administration of an opiate antagonist such as Naloxone or Nalmefene is a specific antidote. Oxygen, intravenous fluids, vasopressors and other supportive measures should be used as indicated

Storage Conditions

Keep it in a cool and dry place, protected from light and moisture.

Drug Classes

Opioid analgesics

Mode Of Action

Nalbun 20 mg/2 ml Hydrochloride is a synthetic potent analgesic. Its analgesic potency is essentially equivalent to that of morphine on a milligram basis. Receptor studies show that Nalbun 20 mg/2 ml binds to mu, kappa, and delta receptors, but not to sigma receptors. Nalbun 20 mg/2 ml is primarily a kappa agonist/partial mu antagonist analgesic.

Pregnancy

Pregnancy category B. The placental transfer of Nalbun 20 mg/2 ml is high and rapid. There are no well-controlled studies in pregnant women. This drug should be used during pregnancy only if clearly needed. Limited data suggest that Nalbun 20 mg/2 ml is excreted in maternal milk but only in a small amount (less than 1% of the administered dose) and with a clinically insignificant effect. Caution should be exercised when Nalbun 20 mg/2 ml is administered to a nursing woman.