Rymin10 mg/5 ml

Description

Indications of Rymin 10 mg/5 ml

Diphenhydramine is indicated for the treatment of followings: Seasonal, perennial, vasomotor rhinitis Urticaria, angioneurotic oedema, anaphylaxis Pruiritic conditions Premedication for emesis and motion sickness Miscellaneous like meniere’s disease and parkinsonism

Theropeutic Class

Sedating Anti-histamine

Pharmacology

Diphenhydramine is an antihistamine with anticholinergic and sedative effects. It competes with histamine for H1-receptor sites on effector cells in the GI tract, blood vessels and respiratory tract.

Dosage & Administration of Rymin 10 mg/5 ml

Adult- Most allergic conditions: 25-50 mg three times a day with a further 50 mg at night. Children- 1 to 5 years of age: 5 mg i.e., 2.5 ml of elixir 4 times a day More than 6 years of age: 10 mg i.e. 5 ml of elixir 4 times a day

Dosage of Rymin 10 mg/5 ml

Adult- Most allergic conditions: 25-50 mg three times a day with a further 50 mg at night. Children- 1 to 5 years of age: 5 mg i.e., 2.5 ml of elixir 4 times a day More than 6 years of age: 10 mg i.e. 5 ml of elixir 4 times a day

Interaction of Rymin 10 mg/5 ml

Diphenhydramine administration significantly reduces the absorption of the antituberculous agent para-aminosalicyclic acid (PAS) from the gastrointestinal tract. CNS depressants may potentiate the sedative action of Diphenhydramine. Anticholinergic drugs may potentiate Diphenhydramine’s anticholinergic side effects.

Contraindications

Known hypersensitivity to Rymin 10 mg/5 ml, Ammonium chloride is contra-indicated in presence of impaired hepatic or renal function.

Side Effects of Rymin 10 mg/5 ml

Side effect includes sedation, dizziness, tinnitus, fatigue, ataxia, blurred vision, diplopia, euphoria, and epigastric discomfort.

Pregnancy & Lactation

Category B: There are no adequate and well controlled studies in pregnant women using Rymin 10 mg/5 ml. Therefore, Rymin 10 mg/5 ml should be used in pregnancy only if clearly needed. Diphenhydramine hydrochloride has been reported to be excreted in breast milk and thus, use of Rymin 10 mg/5 ml in lactating mother is not recommended.

Precautions & Warnings

Caution should be exercised with patients in whom drowsiness is undesirable e.g., drivers, machine operators. Concomitant consumption of alcohol or central nervous system (CNS) depressants will potentiate drowsiness.

Overdose Effects of Rymin 10 mg/5 ml

Symptoms: Impaired consciousness? psychosis, seizures, antimuscarinic symptoms (e.g. mydriasis, tachycardia, tachyarrhythmias), resp failure, rhabdomyolysis; acute delirium with visual and auditory hallucination (topical). Management: Supportive and symptomatic treatment. Convulsions and marked CNS stimulation may be treated with IV diazepam.

Storage Conditions

Store between 15-30° C. Protect from moisture.

Drug Classes

Sedating Anti-histamine

Mode Of Action

Diphenhydramine is an antihistamine with anticholinergic and sedative effects. It competes with histamine for H1-receptor sites on effector cells in the GI tract, blood vessels and respiratory tract.

Pregnancy

Category B: There are no adequate and well controlled studies in pregnant women using Rymin 10 mg/5 ml. Therefore, Rymin 10 mg/5 ml should be used in pregnancy only if clearly needed. Diphenhydramine hydrochloride has been reported to be excreted in breast milk and thus, use of Rymin 10 mg/5 ml in lactating mother is not recommended.