Racetril100 mg

Description

Indications of Racetril 100 mg

Racetril 100 mg is indicated for the symptomatic treatment of acute diarrhea.

Theropeutic Class

Anti-diarrhoeal

Pharmacology

Racetril 100 mg increases the availability of endogenous opioids (enkephalins) by inhibiting the membrane-bound enkephalinase. The enkephalins in turn mediate their effect through ? receptor ( delta opioid receptor) activation that induces a selective increase in Cl absorption by inhibiting adenylate cyclase.Onset: 30 min (plasma enkephalinase inhibition).

Dosage & Administration of Racetril 100 mg

Adults: One capsule initially, regardless of the time of day. Then one capsule three times daily preferably before the main meals. Children (from 3 months of age): Racetril 100 mg granules should be administered together with oral rehydration. The recommended dose is determined according to body weight: 1.5 mg/kg per administration, three times daily. Infants less than 9 kg: one 10 mg sachet 3 times daily. Infants from 9 kg to 13 kg: two 10 mg sachets 3 times daily. Children from 13 kg to 27 kg: one 30mg sachet 3 times daily. Children of more than 27 kg: two 30mg sachets 3 times daily.

Dosage of Racetril 100 mg

Adults: One capsule initially, regardless of the time of day. Then one capsule three times daily preferably before the main meals. Children (from 3 months of age): Racetril 100 mg granules should be administered together with oral rehydration. The recommended dose is determined according to body weight: 1.5 mg/kg per administration, three times daily. Infants less than 9 kg: one 10 mg sachet 3 times daily. Infants from 9 kg to 13 kg: two 10 mg sachets 3 times daily. Children from 13 kg to 27 kg: one 30mg sachet 3 times daily. Children of more than 27 kg: two 30mg sachets 3 times daily.

Interaction of Racetril 100 mg

No drug interactions found. Joint treatment with Racetril 100 mg and Loperamide or Nifuroxazide does not modify the kinetics of Racetril 100 mg.

Contraindications

Hypersensitivity to Racetril 100 mg, or to any of the excipients.

Side Effects of Racetril 100 mg

Headache, erythema multiforme, urticaria, angioedema may be seen.

Pregnancy & Lactation

Due to a lack of clinical data, Racetril 100 mg should not be administered to pregnant or breastfeeding women.

Precautions & Warnings

The administration of Racetril 100 mg does not modify the usual rehydration regimens. The presence of bloody stools and fever may indicate the presence of invasive bacteria as a reason for diarrhea or the presence of other severe disease. Racetril 100 mg has not been tested in antibiotic-associated diarrhea and should therefore not be administered under these conditions. Caution should be taken in patients with renal or liver impairment.

Overdose Effects of Racetril 100 mg

No cases of overdose have been reported. In adults, single doses above 2 g which is equivalent to 20 times the therapeutic dose, have been administered, and no harmful effects have been described.

Drug Classes

Anti-diarrhoeal

Mode Of Action

Racetril 100 mg increases the availability of endogenous opioids (enkephalins) by inhibiting the membrane-bound enkephalinase. The enkephalins in turn mediate their effect through ? receptor ( delta opioid receptor) activation that induces a selective increase in Cl absorption by inhibiting adenylate cyclase.Onset: 30 min (plasma enkephalinase inhibition).

Pregnancy

Due to a lack of clinical data, Racetril 100 mg should not be administered to pregnant or breastfeeding women.