Torsid20 mg

Description

Indications of Torsid 20 mg

Torsid 20 mg is indicated for the treatment of edema associated with congestive heart failure, renal disease, or hepatic disease. Torsid 20 mg is indicated for the treatment of hypertension alone or in combination with other antihypertensive agents.

Theropeutic Class

Loop diuretics

Pharmacology

Torsid 20 mg acts within the lumen of the thick ascending portion of the loop of Henle, where it inhibits the Na+/K+/2CI carrier system. Torsid 20 mg increases the urinary excretion of sodium, chloride and water, but it does not significantly alter glomerular filtration rate, renal plasma flow or acid-base balance.

Dosage & Administration of Torsid 20 mg

Edema associated with heart failure: The recommended initial dose is Torsid 20 mg 10 mg or 20 mg once daily. If the diuretic response is inadequate, titrate upward by approximately doubling until the desired diuretic response is obtained.Edema associated with chronic renal failure: The recommended initial dose is Torsid 20 mg 20 mg once daily. If the diuretic response is inadequate, titrate upward by approximately doubling until the desired diuretic response is obtained.Edema associated with hepatic cirrhosis: The recommended initial dose is Torsid 20 mg 5 mg or 10 mg once daily, administered together with an aldosterone antagonist or a potassium-sparing diuretic. If the diuretic response is inadequate, titrate upward by approximately doubling untilthe desired diuretic response is obtained.Treatment of Hypertension: The recommended initial dose is 5 mg once daily. If the 5 mg dose does not provide adequate reduction in blood pressure within 4 to 6 weeks, increase to 10 mg once daily. If the response to 10 mg is insufficient, add another antihypertensive agent to the treatment regimen.

Dosage of Torsid 20 mg

Edema associated with heart failure: The recommended initial dose is Torsid 20 mg 10 mg or 20 mg once daily. If the diuretic response is inadequate, titrate upward by approximately doubling until the desired diuretic response is obtained.Edema associated with chronic renal failure: The recommended initial dose is Torsid 20 mg 20 mg once daily. If the diuretic response is inadequate, titrate upward by approximately doubling until the desired diuretic response is obtained.Edema associated with hepatic cirrhosis: The recommended initial dose is Torsid 20 mg 5 mg or 10 mg once daily, administered together with an aldosterone antagonist or a potassium-sparing diuretic. If the diuretic response is inadequate, titrate upward by approximately doubling untilthe desired diuretic response is obtained.Treatment of Hypertension: The recommended initial dose is 5 mg once daily. If the 5 mg dose does not provide adequate reduction in blood pressure within 4 to 6 weeks, increase to 10 mg once daily. If the response to 10 mg is insufficient, add another antihypertensive agent to the treatment regimen.

Interaction of Torsid 20 mg

Patients receiving high doses of salicylates may experience salicylate toxicity when Torsid 20 mg is concomitantly administered. If Torsid 20 mg and cholestyramine should be co-administered, administer Torsid 20 mg at least one hour before or 4 to 6 h after cholestyramine administration. Also, coadministration of Torsid 20 mg with ACE inhibitors or Angiotensin receptor blockers can increase the risk of hypotension and renal impairment.

Contraindications

Torsid 20 mg is contraindicated in patients with known hypersensitivity to Torsid 20 mg. It is contraindicated in patients who are anuric or with hepatic coma.

Pregnancy & Lactation

Pregnancy Category: BUse in Lactation: It is not known whether Torsid 20 mg is excreted in human milk. Caution should be exercised when Torsid 20 mg is administered to a nursing woman.

Precautions & Warnings

Hypotension: Excessive diuresis may cause potentially symptomatic dehydration, blood volume reduction and hypotension.Electrolyte and Metabolic Abnormalities: Torsid 20 mg can cause symptomatic hypokalemia, hyponatremia and hypochloremic alkalosis.

Storage Conditions

Protect from light and moisture. Store below 30°C. Keep the medicine out of reach of children.

Drug Classes

Loop diuretics

Mode Of Action

Torsid 20 mg acts within the lumen of the thick ascending portion of the loop of Henle, where it inhibits the Na+/K+/2CI carrier system. Torsid 20 mg increases the urinary excretion of sodium, chloride and water, but it does not significantly alter glomerular filtration rate, renal plasma flow or acid-base balance.

Pregnancy

Pregnancy Category: BUse in Lactation: It is not known whether Torsid 20 mg is excreted in human milk. Caution should be exercised when Torsid 20 mg is administered to a nursing woman.