Adecard 6 mg/2 ml

Adecard 6 mg/2 ml

Generic: Adenosine

Manufacturer

Popular Pharmaceuticals Ltd.

৳ 150

Side Effects

Cardiovascular: Facial flushing, headache, sweating, palpitations, chest pain, hypotension. Respiratory: Shortness of breath/dyspnea, chest pressure, hyperventilation, head pressure.

Central Nervous System: Lightheadedness, dizziness, tingling in arms, numbness, apprehension, blurred vision, burning sensation, heaviness in arms, neck and back pain.

Gastrointestinal: Nausea, metallic taste, tightness in throat, pressure in groin. In post-market clinical experience with Adecard, cases of prolonged asystole, ventricular tachycardia, ventricular fibrillation, transient increase in blood pressure, bradycardia, hypotension, atrial fibrillation and bronchospasm, in association with Adecard use, have been reported.

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Description

Indications

Intravenous Adecard is indicated for the following: Conversion to sinus rhythm of paroxysmal supraventricular tachycardia (PSVT), including that associated with accessory bypass tracts (Wolff-Parkinson-White Syndrome).

Pharmacology

This preparation is a sterile, nonpyrogenic solution for rapid bolus intravenous injection. Adenosine injection slows conduction time through the A-V node, can interrupt the reentry pathways through the A-V node, and can restore normal sinus rhythm in patients with paroxysmal supraventricular tachycardia.

Dosage & Administration

Adult:

  • Initial dose: 6 mg given as rapid IV bolus (administered over 1-2 second period).
  • Repeat administration: If the first dose does not result in elimination of the supraventricular tachycardia within 1-2 minutes, 12 mg should be given as rapid intravenous bolus. This 12 mg dose may be repeated for second time if required.

Pediatric: The dosages used in neonates, infants, children and adolescents were equivalent to those administered to adults on a weight basis.

  • Body weight < 50 kg: Initial dose – 0.05 to 0.1 mg/kg as a rapid IV bolus given either centrally or peripherally. A saline flush should follow.
  • Body weight > 50 kg: The adult dose is recommended. Doses greater than 12 mg are not recommended for adult and pediatric patients.

Repeat administration: If conversion of PSVT does not occur within 1-2 minutes, additional bolus injections of adenosine can be administered at incrementally higher doses, increasing the amount given by 0.05 to 0.1 mg/kg. A saline flush should follow. This process should continue until sinus rhythm is established or a maximum single dose of 0.3 mg/kg is used.

Interaction

Intravenous Adecard injection has been effectively administered in the presence of other cardioactive drugs, such as Quinidine, beta- adrenergic blocking agents, Calcium channel blocking agents and angiotensin converting enzyme inhibitors without any change in the adverse reaction profile. Digoxin and Verapamil use may be rarely associated with ventricular fibrillation when combined with Adecard. Because of the potential for additive or synergistic depressant effects on the SA and AV nodes, however, Adecard should be used with caution in the presence of these agents. The use of Adecard in patients receiving Digitalis may be rarely associated with ventricular fibrillation. The effects of Adecard are antagonized by Methylxanthines, such as, Caffeine and Theophylline.

Contraindications

Intravenous Adenosine is contraindicated in:

  • Second- or third-degree A-V block (except in patients with a functioning artificial pacemaker).
  • Sinus node disease, such as sick sinus syndrome or symptomatic bradycardia (except in patients with a functioning artificial pacemaker).
  • Known hypersensitivity to Adenosine.

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